Table 4. Simulation parameter settings.

		Causal %
Genetic effect	Study $\left(c_{\ell }\right)$	5	10	20	50
Homogeneous	1 $\left(c_1\right)$	0.475	0.375	0.25	0.175
	2 $\left(c_2\right)$	0.475	0.375	0.25	0.175
	3 $\left(c_3\right)$	0.475	0.375	0.25	0.175
Heterogeneous	1 $\left(c_1\right)$	0.475	0.375	0.25	0.175
	2 ($c_2$)	$0.475+0.15$	$0.375+0.15$	$0.25+0.15$	$0.175+0.15$
	3 $\left(c_3\right)$	$0.475-0.15$	$0.375-0.15$	$0.25-0.15$	$0.175-0.15$

The constants $c_{\ell }$ in ${\beta }_{\ell }=c_{\ell }\left|{\text{log}}_{10}\left(\text{MAF}\right)\right|/2$ of power simulations, $\ell =1,2,3$, are given for two cases: (1) homogeneous genetic effect and (2) heterogeneous genetic effect.