Table 3.

Studies of Plasmodium vivax

ICEMR/region	Drug efficacy trials		Ex vivo drug sensitivity	Drug resistance polymorphisms
	ACT	CQ/primaquine		pvmdr1	pvdhfr
Southeast Asia	No	Yes	Yes	Yes	No
South Asia	Yes	Yes	Yes	Yes	Yes
PNG	AL, DP, ART/NQ, ART-SP	CQ-SP and AQ-SP, no primaquine	No	Yes	Yes

ACT = artemisinin-based combination therapy; AL = artemether/lumefantrine; ART = artemisinin; AQ = amodiaquine; CQ = chloroquine; DP = dihydroartemisinin/piperaquine; ICEMR = the International Centers of Excellence for Malaria Research; MQ = mefloquine; NQ = naphthoquine; PNG = Papua New Guinea; SP = sulfadoxine/pyrimethamine.