Table 1. Genotype-dependent differences in mitochondrial morphology.

Stage of Necrosis		KO	WT	P-value §
Early*
	Total Number of Foci	20	18
	Disrupted Cristae	20	18	1.000
	Fusion / Fission	2	3	0.6525
	Hydroxyapatite-like deposits	18	0	<0.0001
Mid †
	Total Number of Foci	55	65
	Foci with Intact Mitochondria	54	64
	Disrupted Cristae	54	64	1.000
	Fusion / Fission	4	1	0.1773
	Hydroxyapatite-like deposits	45	10	<0.0001
Late ‡
	Total Number of Foci	38	35
	Foci with Intact Mitochondria	22	21
	Abnormal Shape	20	17	0.8163
	Hydroxyapatite-like deposits	26	0	<0.0001

*Plasma membrane intact, majority of mitochondria intact (Fig 7A)

^†Plasma membrane intact, diminished mitochondrial presence (Fig 7B)

^‡Disruption of plasma membrane, lack of or very few mitochondria (Fig 7C)

^§Chi-square test.