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. 2015 Sep 17;13:104. doi: 10.1186/s12958-015-0102-4

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© Ferrero et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — VEGF mRNA is not altered by the dopamine receptor 2 agonist Cabergoline. Time-course experiments designed to study the effects of the dopamine receptor 2 agonist (D2-ag) Cabergoline (Cb2) on VEGF mRNA stability (expressed as the percentage of VEGF mRNA degradation) in LGCs. LGCs (n = 6) were pre-incubated with actinomycin D (ActD), then treated with Cb2, hCG, and ActD for 1, 2, or 4 h or untreated. The amount of VEGF cDNA at time point 0 was assigned a value of 100 and the percentage of degraded mRNA was estimated according to variations in the Ct determined by QF-RT-PCR. No significant differences in VEGF mRNA stability were observed in LGCs treated with Cb2 compared to untreated LGCs