Table 3.
Significant group differences and overlap by task type. Only statistically significant coordinates are included.
| Cluster | Cluster Size (mm3) | Extent & Weighted Center (x, y, z) | Local Extrema (x, y, z) | Location | ALE Value (x10−3) | Lobular Function |
|---|---|---|---|---|---|---|
| Emotion | ||||||
| Controls>Patients | ||||||
| Cluster 1 | 440 | From (−18, −78, −40) to (−10, −70, −30) centered at (−14.9, −74.01, −36.18) | −12, −74, −38 | Crus II | 1956.55 | Cognitive: WM, LNG |
| −16.11, −73.94, −35.33 | Crus I | 1821.04 | Cognitive: WM, EF, LNG, EMO | |||
| Cluster 2 | 272 | From (−32, −80, −38) to (−24, −74, −32) centered at (−27.26, −77.42, −35.96) | −29.6, −76.8, −37.6 | Crus II | 2241.40 | Cognitive: WM, LNG |
| Patients>Controls | ||||||
| Cluster 1 | 144 | From (−34, −74, −18) to (−28, −70, −24) centered at (−31.44, −72.11, −15.99) | −31.44, −72.11, −15.99 | Cortex | 1726.82 | -- |
| Overlap | ||||||
| Cluster 1 | 72 | From (36, −50, −28) to (40, −48, −26) centered at (38.71, −48.88, −27.09) | 38, −48, −26 | Lobule VI | 7.87 | Cognitive & Motor: WM, LNG, EF |
| Executive Function/Attention | ||||||
| Patients>Controls | ||||||
| Cluster 1 | 184 | From (24, −50, −30) to (30, −44, −26) centered at (26.94, −46.52, −28.09) | 25.33, −46.22, −28.89 | Lobule VI | 1684.49 | Cognitive & Motor: WM, LNG, EF |
| 30, −48, −27 | Lobule VI | 1656.60 | Cognitive & Motor: WM, LNG, EF | |||
| Overlap | ||||||
| Cluster 1 | 504 | From (−32, −74, −28) to (−22, −58, −22) centered at (−26.11, −65.12, −25.11) | −24, −62, −26 | Lobule VI | 9.53 | Cognitive & Motor: WM, LNG, EF |
| −30, −72, −26 | Lobule VI | 7.21 | Cognitive & Motor: WM, LNG, EF | |||
| Cluster 2 | 488 | From (14, −62, −26) to (22, −52, −18) centered at (17.9, −56.79, −22.03) | 18, −56, −22 | Lobule VI | 10.31 | Cognitive & Motor: WM, LNG, EF |
| Cluster 3 | 248 | From (−4, −76, −22) to (4, −70, −18) centered at (−.22, −73.07, −19.97) | 2, −72, −20 | Lobule VI | 7.96 | Cognitive & Motor: WM, LNG, EF |
| Language | ||||||
| Controls>Patients | ||||||
| Cluster 1 | 88 | From (−4, −76, −42) to (0, −70, −40) centered (−1.3, −73.42, −40.7) | −2, −70, −42 | Lobule VIIIa/VIII b | 2012.19 | Secondary motor representation |
| −2, −75, −40 | Lobule VIIIa | 1991.74 | Secondary motor representation | |||
| Patients>Controls | ||||||
| Cluster 1 | 152 | From (30, −70, −38) to (34, −64, −34) centered at (31.97, −67.02, −35.5) | 31.5, −66.25, −34.75 | Crus I | 2115.35 | Cognitive: WM, EF, LNG, EMO |
| Motor | ||||||
| Controls>Patients | ||||||
| Cluster 1 | 712 | From (−14, −74, −44) to (−4, −64, −30) centered at (−9.02, −69.32, −37.07) | −11.11, −71.78, −34.67 | Crus II | 1980.92 | Cognitive: WM, LNG |
| −12, −66, −36 | Lobule VIIIa | 1839.78 | Secondary motor representation | |||
| −7.81, −68, −39.37 | Lobule VIII | 1738.06 | Secondary motor representation | |||
| Cluster 2 | 160 | From (−32, −76, −40) to (−26, −70, −36) centered at (−28.61, −73.45, −37.63) | −28, −73, −36 | Crus I | 2117.70 | Cognitive: WM, EF, LNG, EMO |
| −26, −72, −40 | Crus I | 1980.92 | Cognitive: WM, EF, LNG, EMO | |||
| −32, −76, −38 | Crus I | 1959.96 | Cognitive: WM, EF, LNG, EMO | |||
| Cluster 3 | 88 | From (−20, −66, −34) to (−16, −62, −30) centered at (−18.03, −64.61, −31.64) | −20, −66, −32 | Lobule VI | 2154.51 | Cognitive & Motor: WM, LNG, EF |
| −16, −62, −32 | Lobule VI | 1738.06 | Cognitive & Motor: WM, LNG, EF | |||
| Patients>Controls | ||||||
| Cluster 1 | 768 | From (−30, −58, −26) to (−16, −50, −16) centered at (−22.53, −53.53, −21.08) | −19, −52.2, −19.4 | Lobule VI | 2404.38 | Cognitive & Motor: WM, LNG, EF |
| −26.8, −51.2, −21.6 | Lobule VI | 2151.97 | Cognitive & Motor: WM, LNG, EF | |||
| −20, −50, −24 | Lobule V | 2110.68 | Motor | |||
| −25, −58, −21 | Lobule VI | 1857.78 | Cognitive & Motor: WM, LNG, EF | |||
| Working Memory | ||||||
| Controls>Patients | ||||||
| Cluster 1 | 1216 | From (−44, −66, −48) to (−30, −54, −36) centered at (−37.19, −61.22, −42.67) | −40, −60, −38 | Crus I | 2280.13 | Cognitive: WM, EF, LNG, EMO |
| −37.85, −60.58, −42.88 | Crus II | 2226.21 | Cognitive: WM, LNG | |||
| Cluster 2 | 88 | From (36, −66, −32) to (42, −62, −28) centered at (38.35, −64.34, −30.17) | 38, −64, −30 | Crus I | 1888.19 | Cognitive: WM, EF, LNG, EMO |
| 42, −66, −32 | Crus I | 1787.85 | Cognitive: WM, EF, LNG, EMO | |||
| Overlap | ||||||
| Cluster 1 | 184 | From (−40, −70, −42) to (−32, −66, −38) centered at (−36.4, −67.81, −39.81) | −36, −68, −40 | Crus I | 8.98 | Cognitive: WM, EF, LNG, EMO |
| Cluster 2 | 128 | From (44, −64, −26) to (48, −58, −22) centered at (45.98, −60.99, −24.52) | 46, −60, −24 | Crus I | 7.40 | Cognitive: WM, EF, LNG, EMO |
| Cluster 3 | 64 | From (40, −74, −40) to (40, −70, −36) centered at (40, −71.7, −38.22) | 50, −70, −38 | Crus I | 7.17 | Cognitive: WM, EF, LNG, EMO |
The functional category associated with each lobule is based on investigations of the cerebellar functional topography (Stoodley & Schmahmann, 2009; Stoodley et al., 2012). However, these studies were not exhaustive and the regions may be involved in other functions. Default mode network (DMN) associations are based off of resting state connectivity analyses (Bernard et al., 2012; Buckner, Krienen, Castellanos, Diaz, & Yeo, 2011). WM: working memory; EF: executive function; EMO: emotion; LNG: language