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. 2015 Aug 28;16(1):180. doi: 10.1186/s13059-015-0741-y

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© Fortin and Hansen. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The methylation correlation signal is a better predictor of A/B compartments than the average methylation signal. The figure displays data on all of chromosome 14 at 100-kb resolution. a The smoothed, average methylation signal on the beta-value scale for the 450 k-EBV dataset. The signal has been centered by the mean and the sign has been reversed so that values close to one correspond to low methylation values. b The first eigenvector of the HiC-EBV-2014 Hi-C dataset. c The smoothed first eigenvector of the binned correlation matrix of the 450 k-EBV dataset. We see that (c) correlates better with (b) than (a)