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. 2015 Sep 18;15:184. doi: 10.1186/s12862-015-0464-4

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© Diaz and Trainor. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — C. calyptratus autopodial Sonic Hedgehog (Shh) expression. Wholemount in situ hybridization indicates that Shh is expressed in a similar pattern to other amniotes along the posterior margin of the developing limb within the Zone of Polarizing Activity (ZPA) in the hands (a, c) and feet (b, d). Significantly, the expression of Shh is lost upon distal flattening of the limb bud in both the hands (e, g) and feet (f, h)