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. 2015 Sep 18;15:184. doi: 10.1186/s12862-015-0464-4

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© Diaz and Trainor. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — C. calyptratus Gremlin 1 (Grem1) expression during autopodial morphogenesis. Grem1 is expressed in the mesenchyme of the autopodium anterior to the ZPA where a feedback loop is known to be present between Grem1 and SHH, Bmps, and FGF8 (a-f). Grem1 appears to decrease its anterior expression during digital plate formation in the forelimb (e) and hindlimb (f). During distal flattening and cleft formation, Grem1 does not appear ectopically between syndactylous digits (g-l)