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. 2015 Sep 17;8:151. doi: 10.1186/s13068-015-0334-8

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© Faraji et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Substrate competition for a shared enzyme, combined with product inhibition. The accumulation of H lignin in the 4CL transgenic line calls for a regulatory mechanism that guides the flow towards the upper branch of the pathway. Direct activation or an inhibited inhibitor can achieve this result. Simulation results support the second option