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. 2015 Sep 17;8:151. doi: 10.1186/s13068-015-0334-8

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© Faraji et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Parallel reactions catalyzed by 4CL. The observed simultaneous accumulation of 4CL substrates and decrease in coniferaldehyde in COMT transgenic lines can be explained with the assumption of an inhibitory effect on the reactions catalyzed by 4CL. 5-OH-ferulic acid could be a candidate for this role. Although 5-OH-ferulic acid is not a substrate for 4CL in switchgrass, it has a similar molecular shape as ferulic acid, so that high concentrations of 5-OH-ferulic acid might exert competitive inhibition that is comparable to the inhibitory effects of ferulic acid