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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Lancet Neurol. 2015 Jun 23;14(8):795–803. doi: 10.1016/S1474-4422(15)00144-1

Table 4. Frequently occurring adverse events.

Placebo 15 mg pioglitazone 45 mg pioglitazone Total
Oedema 9 (13%) 4 (6%) 13 (19%) 26 (12%)
Cardiovascular events 8 (11%) 4 (6%) 6 (9%) 18 (9%)
Diarrhoea 3 (4%) 7 (10%) 3 (4%) 13 (6%)
Nausea 3 (4%) 6 (8%) 7 (10%) 16 (8%)
Raised blood creatine phosphokinase 11 (15%) 12 (17%) 7 (10%) 30 (14%)
Dizziness 6 (8%) 5 (7%) 6 (9%) 17 (8%)
Fatigue 3 (4%) 8 (11%) 2 (3%) 13 (6%)

Data are n (%) of patients.