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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: ACS Chem Biol. 2015 Feb 20;10(5):1217–1226. doi: 10.1021/cb500843r

Figure 1.

Figure 1

TOMM gene clusters and the biosynthetic pathway. (A) Open reading frame diagram showing the organization of several TOMM gene clusters, grouped by function of the mature TOMM. The letters over each gene correspond to the name of the sag genes in S. pyogenes. The function of each gene is color-coded in the legend. (B) Sequences of the precursor peptides from the clusters shown in panel A. The putative (*) or known (−) cleavage sites are shown. The residues substituted in SagA to generate SagA-VLPLL are shown in red. SagA, from S. pyogenes; ClosA, from C. botulinum; StaphA, from S. aureus; LlsA, from L. monocytogenes; BamA, from B. amyloliquefaciens. (C) Generalized mechanism of TOMM maturation with SLS as the example. The proteins putatively responsible for each step are shown above each arrow.