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The role of SagE in the processing of pre-SLS. (A) Purified S. pyogenes membranes display proteolytic activity towards SagA. Both wild type (WT) SagA, and to a reduced extent, the predicted cut site mutant SagA-VLPLL, function as cleavage substrates. (B) Lytic activity of E. coli expressing the SLS biosynthetic machinery after a 2 h induction. The hemolytic activity of extracted SLS on erythrocytes is measured by a colorimetric readout of hemoglobin release.
