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Inhibition of SLS production. (A) Hemolytic activity of SLS extracts from S. pyogenes treated with HIV protease inhibitors. Tipranavir is shown separated by a dashed line due to significant growth effects during treatment (Figure S5). Asterisks indicate a P-value < 0.01 relative to the DMSO control. (B) The structure of nelfinavir (1). (C) The proteolytic effect of S. pyogenes membranes treated with nelfinavir on MBP-SagA, relative to a DMSO-treated control.
