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. Author manuscript; available in PMC: 2016 May 15.
Published in final edited form as: ACS Chem Biol. 2015 Feb 20;10(5):1217–1226. doi: 10.1021/cb500843r

Scheme 1.

Scheme 1

Synthesis of nelfinavir. a, i-BuOCOCl, Et3N, THF; CH2N2, Et2O (62%); b, HCl, Et2O; c, NaBH4, THF (62% over two steps); d, KOH, EtOH (91%); e, 6, KOH, IPA, 80 °C (84%); f, 3-hydroxy-2-methylbenzoic acid, EDC, HOBt, THF (66%).