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. Author manuscript; available in PMC: 2015 Sep 18.
Published in final edited form as: J Cardiovasc Pharmacol. 2014 Feb;63(2):132–143. doi: 10.1097/FJC.0000000000000031

Figure 7.

Figure 7

(A) Number of CD45+ leukocytes per μl of blood of ApoeR61h/h/SRB1–/– mice at 1wk pre-HFD and 3.5wk HFD time-points with FTY720-treatment or not. (B) Numbers of B cells, T cells, monocytes (mono) and neutrophils (neutro) per μl of blood at 1wk pre-HFD and 3.5wk HFD time-points. (C) Representative FACS plots of CD45+ blood leukocytes from ApoeR61h/h/SRB1–/– mice after 3.5 weeks of HFD feeding. Shown are gated populations: T cells (CD3+B220–), B cells (CD3–B220+), neutrophils (Ly6G+CD11b+) and monocytes (Ly6G–CD11b+). (D) Numbers of CD4+ and CD8+ T cells per μl of blood after 3.5 weeks of HFD feeding. (E) Percentage of Foxp3+ T cells among CD4+ T cells in the circulation, LN and spleen after 3.5 weeks of HFD feeding. Data are mean ± SEM. * P<0.05, ** P<0.01 vs Control. 1wk pre-HFD = 1week chow diet with FTY720-treatment or not; 3.5wk HFD = 3.5 weeks HFD with FTY720-treatment or not; LN = lymph nodes. HFD = high fat high cholesterol diet.