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. 2010 Dec 15;84(4):783–789. doi: 10.1095/biolreprod.110.088468

FIG. 1.

FIG. 1.

Developmental expression of fetal brain (A) Abcg2 mRNA on E15.5 and E18.5. The error bar represents the mean ± SEM expressed as relative units of mRNA standardized against Gapdh. B) Relative levels of BCRP1 protein expressed on E15.5 and E18.5. The error bar represents the mean ± SEM BCRP1:β-actin ratio. C) Function of fetal brain BCRP1 on E15.5 and E18.5 determined by accumulation of transporter-specific substrate and accumulation of [3H]mitoxantrone (5 mg/kg) in whole fetal brain on E15.5 and E18.5. The error bar represents the mean ± SEM drug ratio (DPM/g fetal brain:DPM/g fetal body). The number in parentheses represents the number of dams in each group. *P < 0.05 versus E15.5. ROD indicates relative optical density.