Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Complications of surgery – adverse events short-term (intraoperative and immediate postoperative)
Systematic review	Women of reproductive years with heavy menstrual bleeding 4 RCTs in this analysis	Sepsis 18/345 (5%) with endometrial resection/ablation 88/276 (32%) with hysterectomy	RR 0.19 95% CI 0.12 to 0.31 P <0.00001	Large effect size	endometrial resection/ablation
Systematic review	Women of reproductive years with heavy menstrual bleeding 3 RCTs in this analysis	Haemorrhage 10/310 (3%) with endometrial resection/ablation 13/245 (5%) with hysterectomy	RR 0.69 95% CI 0.32 to 1.46 P = 0.33		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding 4 RCTs in this analysis	Blood transfusion 3/409 (1%) with endometrial resection/ablation 16/342 (5%) with hysterectomy	RR 0.20 95% CI 0.07 to 0.59 P = 0.0032	Large effect size	endometrial resection/ablation
Systematic review	Women of reproductive years with heavy menstrual bleeding 3 RCTs in this analysis	Pyrexia 9/298 (3%) with endometrial resection/ablation 53/307 (17%) with hysterectomy	RR 0.17 95% CI 0.09 to 0.35 P <0.00001	Large effect size	endometrial resection/ablation
Systematic review	Women of reproductive years with heavy menstrual bleeding 5 RCTs in this analysis	Vault haematoma 2/428 (1%) with endometrial resection/ablation 29/430 (7%) with hysterectomy	RR 0.11 95% CI 0.04 to 0.34 P = 0.000099	Large effect size	endometrial resection/ablation
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Wound haematoma 0/105 (0%) with endometrial resection/ablation 14/97 (14%) with hysterectomy	RR 0.03 95% CI 0.00 to 0.53 P = 0.016	Large effect size	endometrial resection/ablation
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Anaesthetic (not further defined) 0/105 (0%) with endometrial resection/ablation 2/97 (2%) with hysterectomy	RR 0.18 95% CI 0.01 to 3.80 P = 0.27		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding 3 RCTs in this analysis	Fluid overload 18/304 (6%) with endometrial resection/ablation 1/307 (1%) with hysterectomy	RR 9.27 95% CI 2.17 to 39.64 P = 0.0027	Large effect size	hysterectomy
Systematic review	Women of reproductive years with heavy menstrual bleeding 2 RCTs in this analysis	Perforation 4/215 (2%) with endometrial resection/ablation 0/215 (0%) with hysterectomy	RR 5.05 95% CI 0.61 to 42.16 P = 0.13		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Gastrointestinal obstruction/ileus 1/105 (1%) with endometrial resection/ablation 2/97 (2%) with hysterectomy	RR 0.46 95% CI 0.04 to 5.01 P = 0.53		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding 2 RCTs in this analysis	Laparotomy 2/194 (1%) with endometrial resection/ablation 5/189 (3%) with hysterectomy	RR 0.39 95% CI 0.08 to 1.97 P = 0.25		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Cystotomy 0/110 (0%) with endometrial resection/ablation 2/118 (2%) with hysterectomy	RR 0.21 95% CI 0.01 to 4.42 P = 0.32		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding 2 RCTs in this analysis	Cervical laceration 2/199 (1%) with endometrial resection/ablation 0/210 (0%) with hysterectomy	RR 3.16 95% CI 0.33 to 30.10 P = 0.32		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Cardiorespiratory event 0/110 (0%) with endometrial resection/ablation 3/118 (3%) with hysterectomy	RR 0.15 95% CI 0.01 to 2.93 P = 0.21		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Thromboembolic event 0/110 (0%) with endometrial resection/ablation 2/118 (2%) with hysterectomy	RR 0.21 95% CI 0.01 to 4.42 P = 0.32		Not significant
Systematic review	Women of reproductive years with heavy menstrual bleeding Data from 1 RCT	Re-admission/return to surgery 0/110 (0%) with endometrial resection/ablation 3/118 (3%) with hysterectomy	RR 0.15 95% CI 0.01 to 2.93 P = 0.21		Not significant
Pain
Systematic review	Premenopausal women 2 RCTs in this analysis	Surgery pain score with hysterectomy with endometrial ablation Absolute results not reported	MD 2.5 95% CI 2.2 to 2.9 P <0.0001	Effect size not calculated	endometrial ablation