Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Need for further surgery
Systematic review	Premenopausal women with heavy periods 7 RCTs in this analysis	Requirement for any additional surgery 1-year follow-up 24/569 (4%) with second generation 31/459 (7%) with first generation	RR 0.77 95% CI 0.46 to 1.28 P = 0.31		Not significant
Systematic review	Premenopausal women with heavy periods 5 RCTs in this analysis	Requirement for any additional surgery 2-year follow-up 44/556 (8%) with second generation 40/432 (9%) with first generation	RR 0.83 95% CI 0.52 to 1.32 P = 0.43		Not significant
Systematic review	Premenopausal women with heavy periods 3 RCTs in this analysis	Requirement for any additional surgery 2–5 years follow-up 76/367 (21%) with second generation 70/280 (25%) with first generation	RR 0.95 95% CI 0.72 to 1.26 P = 0.74		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Requirement for any additional surgery >5 years follow-up 34/129 (26%) with second generation 51/134 (38%) with first generation	RR 0.69 95% CI 0.48 to 0.99 P = 0.046	Small effect size	second generation
Systematic review	Premenopausal women with heavy periods 4 RCTs in this analysis Subgroup analysis	Requirement for hysterectomy 1-year follow-up 14/401 (4%) with second generation 20/371 (5%) with first generation	RR 0.72 95% CI 0.37 to 1.39 P = 0.33		Not significant
Systematic review	Premenopausal women with heavy periods 4 RCTs in this analysis Subgroup analysis	Requirement for hysterectomy 2-year follow-up 32/522 (6%) with second generation 27/398 (7%) with first generation	RR 0.86 95% CI 0.52 to 1.42 P = 0.55		Not significant
Systematic review	Premenopausal women with heavy periods 4 RCTs in this analysis Subgroup analysis	Requirement for hysterectomy 2–5 years follow-up 60/423 (14%) with second generation 64/335 (19%) with first generation	RR 0.85 95% CI 0.59 to 1.22 P = 0.38		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT Subgroup analysis	Requirement for hysterectomy >5 years follow-up 22/129 (17%) with second generation 38/134 (28%) with first generation	RR 0.60 95% CI 0.38 to 0.96 P = 0.032	Small effect size	second generation