Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Amenorrhoea
Systematic review	Premenopausal women with heavy periods 2 RCTs in this analysis	Amenorrhoea 6-month follow-up 51/118 (43%) with bipolar radiofrequency electrode 6/61 (10%) with balloon ablation	RR 4.39 95% CI 2.00 to 9.66	Moderate effect size	bipolar radiofrequency electrode
Systematic review	Premenopausal women with heavy periods 3 RCTs in this analysis	Amenorrhoea 12-month follow-up 64/145 (44%) with bipolar radiofrequency electrode 11/86 (13%) with balloon ablation	RR 3.78 95% CI 2.07 to 6.91	Moderate effect size	bipolar radiofrequency electrode
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 2–5 years follow-up 39/81 (48%) with bipolar radiofrequency electrode 12/39 (31%) with balloon ablation	RR 1.56 95% CI 0.93 to 2.64		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Median Pictorial Blood Loss Assessment Chart (PBAC) score after treatment 1 year 3 with electrode 21 with balloon	P = 0.2		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 6-month follow-up 56/139 (40%) with microwave ablation 37/138 (27%) with balloon ablation	RR 1.50 95% CI 1.07 to 2.12	Small effect size	microwave ablation
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 1-year follow-up 61/147 (41%) with microwave ablation 51/135 (38%) with balloon ablation	RR 1.10 95% CI 0.82 to 1.47		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean PBAC score 1 year 3 with microwave ablation 4 with balloon ablation	Incidence rate ratio 0.91 95% CI 0.6 to 1.5		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 6-month follow-up 28/76 (37%) with bipolar radiofrequency electrode 12/74 (16%) with hydrothermal ablation	RR 2.27 95% CI 1.25 to 4.12	Moderate effect size	bipolar radiofrequency electrode
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 1-year follow-up 35/75 (47%) with bipolar radiofrequency electrode 17/71 (24%) with hydrothermal ablation	RR 1.95 95% CI 1.21 to 3.15	Small effect size	bipolar radiofrequency electrode
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 2–5 years follow-up 41/74 (55%) with bipolar radiofrequency electrode 23/65 (35%) with hydrothermal ablation	RR 1.57 95% CI 1.06 to 2.31	Small effect size	bipolar radiofrequency electrode
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Amenorrhoea 3-year follow-up 36/50 (72%) with ablative curettage 8/50 (16%) with overcurettage	RR 4.50 95% CI 2.33 to 8.69 See Further information on studies	Moderate effect size	ablative curettage
RCT	104 premenopausal women with heavy menstrual bleeding	Amenorrhoea 10-year follow-up 50/69 (73%) with bipolar radiofrequency electrode 23/35 (66%) with balloon ablation	RR 1.1 95% CI 0.83 to 1.5		Not significant