Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Quality of life
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-12 Physical score 1-year follow-up 52.1 with bipolar radiofrequency electrode 50.5 with balloon ablation	Mean difference +1.60 95% CI –4.27 to +7.47		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-12 Mental score 1-year follow-up 49.5 with bipolar radiofrequency electrode 42.0 with balloon ablation	Mean difference +7.50 95% CI –0.52 to +15.52		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Physical functioning score 1-year follow-up 91 with bipolar radiofrequency electrode 88 with balloon ablation	Mean difference +3.00 95% CI –6.44 to +12.44		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Physical functioning score 2–5 years follow-up 86 with bipolar radiofrequency electrode 84 with balloon ablation	Mean difference +2.00 95% CI –8.26 to +12.26		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Role physical score 1-year follow-up 94 with bipolar radiofrequency electrode 89 with balloon ablation	Mean difference +5.00 95% CI –6.96 to +16.96		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Role physical score 2–5 years follow-up 94 with bipolar radiofrequency electrode 86 with balloon ablation	Mean difference +8.00 95% CI –2.66 to +18.66		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Role emotional score 1-year follow-up 99 with bipolar radiofrequency electrode 95 with balloon ablation	Mean difference +4.00 95% CI –1.92 to +9.92		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Role emotional score 2–5 years follow-up 90 with bipolar radiofrequency electrode 99 with balloon ablation	Mean difference –9.00 95% CI –14.45 to –3.55	Effect size not calculated	balloon ablation
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Social functioning score 1-year follow-up 89 with bipolar radiofrequency electrode 86 with balloon ablation	Mean difference +3.00 95% CI –6.17 to +12.17		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Social functioning score 2–5 years follow-up 88 with bipolar radiofrequency electrode 84 with balloon ablation	Mean difference +4.00 95% CI –5.60 to +13.60		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Mental health score 1-year follow-up 80 with bipolar radiofrequency electrode 80 with balloon ablation	Mean difference 0.00 95% CI –8.03 to +8.03		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Mental health score 2–5 years follow-up 76 with bipolar radiofrequency electrode 81 with balloon ablation	Mean difference –5.00 95% CI –11.39 to +1.39		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Energy/vitality score 1-year follow-up 73 with bipolar radiofrequency electrode 64 with balloon ablation	Mean difference +9.00 95% CI –0.44 to +18.44		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Energy/vitality score 2–5 years follow-up 65 with bipolar radiofrequency electrode 68 with balloon ablation	Mean difference –3.00 95% CI –10.39 to +4.39		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Pain score 1-year follow-up 76 with bipolar radiofrequency electrode 77 with balloon ablation	Mean difference –1.00 95% CI –12.61 to +10.61		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 Pain score 2–5 years follow-up 78 with bipolar radiofrequency electrode 83 with balloon ablation	Mean difference –5.00 95% CI –14.79 to +4.79		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 General health score 1-year follow-up 81 with bipolar radiofrequency electrode 75 with balloon ablation	Mean difference +6.00 95% CI –4.10 to +16.10		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-36 General health score 2–5 years follow-up 77 with bipolar radiofrequency electrode 71 with balloon ablation	Mean difference +6.00 95% CI –5.72 to +17.72		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean quality of life scores (EQ-5D) 0.84 with microwave ablation 0.82 with balloon ablation	Mean difference +0.02 95% CI –0.04 to +0.08		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-12 Physical score 52.8 with microwave ablation 53.5 with balloon ablation	Mean difference –0.70 95% CI –2.64 to +1.24		Not significant
Systematic review	Premenopausal women with heavy periods Data from 1 RCT	Mean SF-12 Mental score 47.6 with microwave ablation 48.8 with balloon ablation	Mean difference –1.20 95% CI –3.67 to +1.27		Not significant