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Universal and domain-specific CNEs. (A,B) Portrayal of the crown view (from the subunit interface) of the X-ray crystal structure of the yeast large ribosomal subunit (Ben-Shem et al. 2011) with the L1 stalk at the upper left. (A) uCNEs that are ≥90% conserved in sequence in all domains of life are indicated. (B) The dsCNEs in Eukarya with ≤50% sequence conservation in Bacteria and Archaea. Also see Supplemental Table S5.
