Fig 3. Approach used to estimate global leptospirosis morbidity and mortality.

We extracted information on leptospirosis disease incidence, case fatality, age and gender distribution of cases and deaths, and the ratios of clinically suspected to laboratory confirmed cases and deaths from studies that met quality assurance criteria. Data outputs are depicted in open boxes. Processes and analyses are depicted in shaded boxes. Equations are detailed in S10 Table.