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Genotypic frequencies of 49A/G SNPs of the CTLA4 gene in TAMG(+) and MG(−) thymomas.
| n | A/A | A/G | G/G | P value for chi-square test | |
|---|---|---|---|---|---|
| TAMG(+) | 31 | 18 (58.06) | 10 (32.26) | 3 (9.68) | 0.0003 |
| MG(−) thymoma | 39 | 5 (12.82) | 25 (64.10) | 9 (23.08) | ns |
The frequency of the +49gain-of-function AA genotype is significantly higher in TAMG(+) than MG(−) thymoma patients. SNPs, single-nucleotide polymorphisms; TAMG, thymoma-associated myasthenia gravis.
