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. 2015 Aug 18;2(9):906–919. doi: 10.1002/acn3.227

Figure 1.

Figure 1

Immune profile of lymphocytes in the peripheral blood (PB) and cerebrospinal fluid (CSF). (A) Proportions of CD45+ lymphocytes, CD3+ T cells (CD3+CD56−), NK cells (CD3−CD56+) and NKT cells (CD3+CD56+) within PB (black symbols) and CSF (red symbols) of control (ctrl, n = 17; closed circles and squares) and HIV patients (HIV,n = 86; open circles and squares) were determined by multicolor flow cytometry as described in Figure S1. (B) Proportions of CD4+ T cells (CD3+CD56−CD4+) and CD8+ T cells (CD3+CD56−CD8+) as well as CD4/CD8 ratio within PB and CSF of control and HIV patients are shown. In addition, CD4/CD8 ratios within PB and CSF according to the grade of neurocognitive impairment are depicted (vertical scatter plot, mean with SEM). P values were calculated using Mann–Whitney test for comparison of two groups, and Kruskal–Wallis test with post hoc Dunn Multiple Comparison analysis for the comparison of three and more groups). Asterisks denote different P values: *P < 0.05; ***P < 0.0001. For detailed statistics see Table S1A and B.