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. 2015 Aug 18;2(9):906–919. doi: 10.1002/acn3.227

Figure 2.

Figure 2

HLA-DR expression on CD4+ and CD8+ T cells. (A) The expression of HLA-DR on CD4+ and CD8+ T cells within PB (black symbols) and CSF (red symbols) of control (ctrl, n = 17; closed circles and squares) and HIV-patients (HIV,n = 86; open circles and squares) were evaluated by flow cytometry. (B) Graphs showing the percentage of HLA-DR-positive CD4+ and CD8+ T cells within PB (closed black symbols) and CSF (open red symbols) of control and HIV-patients according to the virus load (none, <37 copies/mL, >37 copies/mL). P values were calculated using Mann–Whitney test. Asterisks denote different P values: *P < 0.05; **P < 0.01; ***P < 0.0001. (C) Graphs showing the percentage of HLA-DR-positive CD4+ and CD8+ T cells in PB (closed symbols) and CSF (open symbols) of control and virologically suppressed HIV-patients according to the grade of neurocognitive impairment (grade 0–3) and the severity of MRI signal abnormalities (score 0–5). P values were calculated using Mann–Whitney test for comparison of two groups, and Kruskal–Wallis test with post hoc Dunn Multiple Comparison analysis for the comparison of three and more groups. Asterisks denote different P values: *P < 0.05; **P < 0.01; ***P < 0.0001. For detailed statistics see Table S2A–C. PB, peripheral blood; CSF, cerebrospinal fluid; MRI, magnetic resonance imaging.