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. 2015 Aug 18;2(9):906–919. doi: 10.1002/acn3.227

Figure 3.

Figure 3

Distribution of CD4+ and CD8+ T-cell subpopulations within PB (black symbols) and CSF (red symbols) (n = 40; closed circles and squares) of control and HIV patients. The four defined subpopulations were identified by multicolor parametric flow cytometry as described in Figure S2: Naïve (CCR7+/CD45RA+), CM = central memory (CCR7+/CD45RA-), EM = effector memory (CCR7−/CD45RA−) and TEMRA = terminal differentiated effector memory (CCR7−/CD45RA+) T cells (AB) Proportions of each CD4+ (A) and CD8+ (B) T-cell subsets within PB (ctrl, n = 18; closed circles and squares) and CSF (HIV,n = 40; open circles and squares) are shown. P values were calculated using Mann–Whitney test for comparison of two groups, and Kruskal–Wallis test with post hoc Dunn Multiple Comparison analysis for the comparison of three and more groups. Asterisks denote different P values: *P < 0.05; **P < 0.01; ***P < 0.0001. For detailed statistics see Table S3A and B. PB, peripheral blood; CSF, cerebrospinal fluid.