Table 2.

Chromosomes 2 and 6 associations in the CFAS materials

	Vantaa-85+ P-value	CFAS P-value	Combined P-value
Chromosome 2
rs4671212	0.012	0.0035	3.6 × 10−5
rs43155671	2.6 × 10−6	0.12	3.1 × 10−6
GT-haplotype	9.5 × 10−7	0.044	4.0 × 10−7
TG-haplotype	0.016	0.011	1.2 × 10−4
Chromosome 6
rs9277334	1.4 × 10−6	0.48	9.7 × 10−5
rs2301226	1.6 × 10−6	0.24	2.3 × 10−5
rs2071349	2.8 × 10−6	0.075	5.4 × 10−6
rs9277682	5.9 × 10−6	0.97	1.1 × 10−3
rs9277685	1.1 × 10−7	0.97	2.2 × 10−4

The two SNPs that best separated the chromosome 2 locus haplotype (rs7595929, rs4315567) were selected for genotyping by sequencing in the CFAS material. One of the SNPs (rs7595929) failed in sequencing but another SNP rs4671212, was located in the sequenced area. The GT-haplotype was associated with predisposition to and the TG-haplotype with protection from Lewy-related pathology in the Vantaa 85+ and CFAS materials. Seven SNPs with a P-value under 10⁻⁵ were selected from the HLA-DPA1/DPB1 locus, two of the SNPs failed in sequencing in the CFAS material. CFAS, Cognitive Function and Ageing Study; SNPs, single-nucleotide polymorphisms.