Table 2.
MRI volume measurements
| Group | WMV (mL) | CGM (mL) | CTh-right (mm) | CTh-center (mm) | ICV (L) | Cerebellum (mL) | Thalamus (mL) |
|---|---|---|---|---|---|---|---|
| MLD (<16 y/o, n = 14) | 414 (296–498) | 515* * (328–565) | 2.80 (2.16–3.11) | 2.81 (2.19–3.14) | 1.33 (1.08–1.54) | 114 (80–141) | 9.98* * (8.95–14.4) |
| Controls (<16 y/o, n = 14) | 436 (311–540) | 564 (495–681) | 2.86 (2.67–3.11) | 2.89 (2.66–3.02) | 1.36 (1.08–1.62) | 128 (106–170) | 15.5 (11.2–17.0) |
| MLD (>16 y/o, n = 6) | 402* (258–469) | 414* (320–519) | 2.35* (2.10–2.58) | 2.33* (2.04–2.61) | 1.46 (1.11–1.65) | 114* * (100–127) | 10.4* * (8.40–13.3) |
| Controls (>16 y/o, n = 6) | 494 (429–569) | 510 (473–555) | 2.60 (2.47–2.66) | 2.59 (2.50–2.65) | 1.45 (1.28–1.65) | 133 (124–144) | 15.3 (13.0–17.4) |
All values are reported in median values (with range). WMV, white matter volume; CGM, cortical GM volume; CTh, cortical thickness; ICV, intracranial volume; MLD, metachromatic leukodystrophy.
Significantly different (MW-U) compared to age-matched control group are indicated with *P < 0.05 and * *P < 0.01.