Table 2.
Comparative biomarker profiles
| Attribute | Desired | Acceptable |
|---|---|---|
| Specific for paracetamol overdose | APAP-CYS | miR-122, GLDH |
| Sensitivity for ruling out injury | – | miR-122, Keratin-18, HMGB1, |
| Rapidly assayed | – | GLDH, KIM-1 |
| Feasibility of assay | GLDH? | GLDH |
| Invasiveness/sample preparation time | – | miR-122, Keratin-18, HMGB1, GLDH, mtDNA |
| Conserved (translational) across in vitro models, in vivo models and humans | miR-122 | Keratin-18, HMGB1, GLDH, mtDNA, KIM-1 |
| Time after overdose at which it is able to predict the onset of liver injury | – | miR-122, Keratin-18, HMGB1, GLDH |
| Signal to noise | miR-122, Keratin-18, APAP-CYS, HMGB1, GLDH, KIM-1 | – |
| Quantitative relationship with disease severity | – | miR-122, HMGB1 |
| Distinguish benign and clinical relevant increase in ALT | Keratin-18, HMGB1 | miR-122, GLDH |
| Mediator of liver injury | HMGB1 |