Table 3.

Frequency of constitutional symptoms at fixed time intervals following initiation of custirsen infusion on day 8 by treatment group and investigator-assigned intensity

	Group A(Premedication) (n =10)			Group B(increasing dose) (n =11)
Interval post-dose, n (%)	None	Mild	Moderate	None	Mild	Moderate
0–6 h	9 (90)	1 (10)	0	10 (91)	1 (9)	0
6–12 h	6 (60)	4 (40)	0	10 (91)	1 (9)	0
12–18 h	5 (50)	2 (20)	3 (30)	10 (91)	1 (9)	0
18–24 h	5 (50)	1 (10)	4 (40)	10 (91)	1 (9)	0
24–36 h	4 (40)	3 (30)	3 (30)	10 (91)	1 (9)	0