Table 2.

Vincristine pharmacokinetic parameters in chronic lymphocytic leukaemia patients

Patient	Cmax (nM)	AUC(0–6) (nM·h)	Cav(0–6) (nM)
3	688	446	74
4	702	357	60
5	1290	564	94
6	959	559	93
7	1889	780	130
8	876	460	77
Mean ± SD	1067 ± 459	528 ± 146	86 ± 24
Median	918	510	85
(range)	(688–1889)	(357–780)	(60–130)

The Cav_(0–6) was calculated by dividing the AUC_(0–6) by the 6-h duration of the study. The Tmax for all patients was 5 min, with a >90% decrease by 1 h. SD, standard deviation.