Table 3.
Protein binding characteristics, of ceftriaxone in plasma, normalized to albumin, according to Michaelis–Menten kinetics
| n | kd (µmol l–1) | |||||
|---|---|---|---|---|---|---|
| N | r2 | PE | CI95 | PE | CI95 | |
| Healthy volunteers | 28/* | 0.972 | 1.07 | 0.940–1.20 | 51.8 | 43.7–59.8 |
| Intensive care unit patients | ||||||
| – With normal bilirubin | 56/16 | 0.877 | 0.806 | 0.670–0.941 | 46.4 | 31.7–61.1 |
| – Without renal impairment | 21/7 | 0.907 | 1.31 | 0.588–2.02 | 79.5 | 22.7–136 |
| – With renal impairment | 35/9 | 0.787 | 0.962 | 0.693–1.23 | 79.3 | 38.1–121 |
| – With hyperbilirubinaemia | 13/4 | 0.262 | 0.458 | –1.13–2.05 | 222 | 0–1256 |
*
Pooled plasma from six healthy volunteers; four independent experiments with seven concentrations each. CI95, 95% confidence interval; kd, dissociation constant; n, maximum binding capacity per albumin molecule; N, number of analysed data points/number of patients; PE, point estimate.