Table 3.

Mixed model estimates for fixed-effect predictors of apparent oral midazolam clearance (ml min^–1)

			95% Confidence interval
Parameter	Estimate	Standard error	Lower bound	Upper bound	P value
Intercept	78.951	150.011	−219.742	377.644	0.6
CYP3A4*1/*1†	321.074	124.670	72.851	569.296	0.012
Tacrolimus‡	274.770	87.536	100.001	449.531	<0.001
Methylprednisolone dose (mg)	18.897	3.282	12.413	25.381	0.003

^†Vs. CYP3A4*22 carriers;

^‡Vs. cyclosporine.