Table 1.

Definition of low, moderate and high risk of a UGIE in each cohort

UGIE risk group	Definition in LDA cohort	Definition in NSAID cohort
High risk	At least one of the following high risk factors:	At least one of the following high risk factors:
	History of UGIE	History of UGIE
	Age ≥ 80	Age ≥ 70
	Age 70–79 and ≥ one other moderate risk factor	≥ Two moderate risk factors
	Age 60–69 and ≥ two moderate risk factors
Moderate risk	No high risk and at least one of the following moderate risk factors:	No high risk and at least one of the following moderate risk factors:
	Age 70–79	Age 60–69 years
	Use of VKA	History of DM
	Use of clopidogrel	History of HF
	Use of a corticosteroid	History of severe RA
	Use of SSRI	Use of VKA
	Use of spironolactone	Use of LDA
		Use of clopidogrel
		Use of a corticosteroid
		Use of an SSRI
		Use of spironolactone
		High-dose NSAID
Low risk	No moderate or high risk	No moderate or high risk

DM, diabetes mellitus; HF, heart failure; LDA, low-dose aspirin; NSAID, non-steroidal anti-inflammatory drug; RA, rheumatoid arthritis; SSRI, serotonin-reuptake inhibitor; UGIE, upper gastrointestinal event; VKA, vitamin K antagonist.