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. 2015 Sep 10;9:1665–1673. doi: 10.2147/OPTH.S85358

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© 2015 Langford et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Immunoreactivity of tear and serum IgG (green) and IgA (red) from the AHC patient with CA24v-infected cells.

Notes: Arrows show similar differential staining patterns for tear IgG and IgA in CA24v infected HRPE and AGMK cells. (A) Detection of immunoreactive human IgG and/or IgA in CA24v-infected HRPE cells treated with pooled acute tears (collected 1–4 days po). (B) Detection of immunoreactive human IgG and/or IgA in CA24v-infected AGMK cells treated with pooled acute tears. (C) Detection of immunoreactive human IgG and IgA in CA24v-infected HRPE cells treated with tears collected 4 years post-AHC. (D) Detection of immunoreactive human IgG and IgA in CA24v-infected AGMK cells treated with tears collected 5 years post-AHC. (E) Detection of antibody to secretory component (polymeric IgA) in CA24v-infected HRPE cells treated with pooled acute tears. (F) Detection of antibody to secretory component (polymeric IgA) in CA24v-infected HRPE cells treated with tears collected 5 years post-AHC. (G) Detection of CA24v immunoreactive human IgG and IgA in acute serum (collected 11 days po)-treated virus-infected HRPE cells. (H) Detection of CA24v immunoreactive human IgG and IgA in virus-infected HRPE cells treated with the patient’s convalescent serum (collected 5 years post-AHC). Bar =50 µm.

Abbreviations: IgG, immunoglobulin G; IgA, immunoglobulin A; AHC, acute hemorrhagic conjunctivitis; CA24v, coxsackievirus A24 variant; HRPE, human retinal pigmented epithelial; po, post-onset; AGMK, African green monkey kidney.