Table 1.
Conditions in which IL-6 plays a role in pathogenesis
| Uveitic diseases16–18,21,35 |
| Vogt–Koyanagi–Harada syndrome |
| Toxoplasma chorioretinitis |
| Fuchs heterochromic iridocyclitis |
| Behçet disease-associated uveitis |
| Sarcoidosis-associated uveitis |
| Idiopathic uveitis |
| Systemic inflammatory disorders2,36–39 |
| Chronic rheumatoid arthritis |
| Juvenile idiopathic arthritis and Still disease |
| Castleman disease |
| Graves disease |
| Inflammatory bowel disease |
| Systemic sclerosis |
| Relapsing polychondritis |
| Ankylosing spondylitis |
| Infectious diseases40–42 |
| HIV |
| HTLV-1 |
| Cerebral malaria |
| Neoplastic diseases43–46 |
| Breast cancer |
| Colon cancer |
| Prostate cancer |
| Multiple myeloma |
| Neurological diseases47,48 |
| Alzheimers disease |
| Multiple sclerosis |
Note: Modified from Interleukin-6 blockade in ocular inflammatory diseases. Mesquida M, et al; Clin Exp Immunol. 2014;176(3).15 © 2014 John Wiley and Sons Inc.
Abbreviation: HTLV-1, human T-lymphotropic virus-1.