Fig. 1.

Study design. Mice were pretreated for six weeks with iPTH (n = 45) or a vehicle (n = 45), and the same treatment modality was continued post-implantation for the remainder of the study in seventy-six of the mice. One mouse died in each treatment group during the early injection period. At week 0, a baseline group (n = 6 per treatment) was killed for microCT analysis. A tibial titanium implant was inserted into the proximal part of the tibia of the remaining mice, which were then killed at one, two, and four weeks after implantation surgery. The sample size for each outcome measure is shown. microCT= micro-computed tomography, IHC = immunohistochemistry, BSE = backscattered electron microscopy, and MT = mechanical testing.