TABLE I.
Results of MicroCT of Cancellous Bone
| Mean (95% CI) |
P Value (Student t Test or ANOVA)* |
||||
| Vehicle Group | iPTH Group | Treatment | Duration | Treatment*Duration | |
| Bone volume fraction (%) | |||||
| Epiphysis (baseline) | 34.2 (32.3, 36.1) | 45.0 (43.1, 46.8) | 0.005 | — | — |
| Metaphysis (baseline) | 9.02 (8.55, 9.50) | 8.60 (7.59, 9.61) | N.S. | — | — |
| Peri-implant | <0.001 | N.S. | N.S. | ||
| Wk 1 | 21.9 (13.4, 30.3) | 28.7 (25.4, 31.9) | |||
| Wk 2 | 18.5 (14.5, 22.5) | 35.1 (31.6, 38.6) | |||
| Wk 4 | 15.3 (11.0, 19.6) | 33.4 (29.0, 37.9) | |||
| Distal to implant | <0.001 | N.S. | 0.015 | ||
| Wk 1 | 23.9 (7.35, 40.5) | 39.3 (33.6, 44.9)† | |||
| Wk 2 | 12.7 (9.57, 15.9) | 41.1 (36.0, 46.2)† | |||
| Wk 4 | 9.75 (5.50, 14.0)‡ | 43.7 (37.7, 49.8)† | |||
| Trabecular number (mm−1) | |||||
| Epiphysis (baseline) | 8.19 (5.89, 10.5) | 8.95 (7.60, 10.3) | N.S. | — | — |
| Metaphysis (baseline) | 3.82 (3.68, 3.96) | 3.77 (3.49, 4.04) | N.S. | — | — |
| Peri-implant | <0.001 | 0.018 | N.S. | ||
| Wk 1 | 9.98 (6.34, 13.6) | 14.7 (11.9, 17.5) | |||
| Wk 2 | 8.47 (6.75, 10.2) | 16.4 (15.0, 17.8) | |||
| Wk 4§ | 6.17 (4.48, 7.85) | 14.4 (12.6, 16.1) | |||
| Distal to implant | <0.001 | N.S. | N.S. | ||
| Wk 1 | 7.97 (3.05, 12.9) | 9.78 (7.46, 12.1) | |||
| Wk 2 | 4.19 (3.76, 4.61) | 8.73 (7.05, 10.4) | |||
| Wk 4 | 4.65 (3.73, 5.57) | 10.8 (8.45, 13.2) | |||
| Trabecular thickness (μm) | |||||
| Epiphysis (baseline) | 57.5 (56.7, 58.3) | 61.3 (58.3, 64.2) | 0.030 | — | — |
| Metaphysis (baseline) | 43.6 (41.7, 45.4) | 39.6 (36.6, 42.7) | 0.031 | — | — |
| Peri-implant | N.S. | <0.001 | N.S. | ||
| Wk 1 | 28.0 (26.5, 29.6) | 28.5 (26.8, 30.2) | |||
| Wk 2 | 27.5 (26.1, 28.8) | 29.0 (28.0, 30.0) | |||
| Wk 4§# | 32.4 (30.9, 33.9) | 31.7 (30.4, 32.9) | |||
| Distal to implant | <0.001 | N.S. | N.S. | ||
| Wk 1 | 43.7 (36.2, 51.3) | 44.8 (41.8, 47.7) | |||
| Wk 2 | 40.4 (37.8, 42.9) | 48.0 (46.1, 49.8) | |||
| Wk 4 | 38.8 (33.9, 43.8) | 47.7 (45.0, 50.5) | |||
| Tissue mineral density (mg HA cm−3) | |||||
| Epiphysis (baseline) | 951 (935, 968) | 928 (920, 936) | 0.013 | — | — |
| Metaphysis (baseline) | 913 (903, 924) | 882 (862, 901) | 0.013 | — | — |
| Peri-implant | N.S. | 0.001 | N.S. | ||
| Wk 1 | 963 (955, 970) | 961 (956, 967) | |||
| Wk 2# | 976 (970, 982) | 969 (964, 973) | |||
| Wk 4§ | 964 (960, 969) | 965 (959, 971) | |||
| Distal to implant | 0.003 | <0.001 | N.S. | ||
| Wk 1 | 753 (723, 782) | 735 (706, 763) | |||
| Wk 2# | 829 (816, 842) | 803 (790, 815) | |||
| Wk 4# | 816 (800, 833) | 805 (794, 816) | |||
*
N.S. = not significant.
†
Significantly different from the value in the vehicle group at the same time point as shown by post hoc testing.
‡
Significantly different from the value in the same treatment group at week 1 as shown by post hoc testing.
§
Significantly different from the value at week 2, independent of treatment, as shown by post hoc testing.
#
Significantly different from the value at week 1, independent of treatment, as shown by post hoc testing.