Table 1.
Variable, N (%) | Total (N=25,603) | HDV Not Tested (N=23,595) | HDV Negative (N=1,935) | HDV Positive (N=73) | P value* |
---|---|---|---|---|---|
Age (M, SD) | 52 (12) | 52 (12) | 52 (12) | 51 (10) | 0.52 |
Male | 24,140 (94) | 22,202 (94) | 1,867 (96) | 71 (97) | <0.001 |
<0.001 | |||||
Race | |||||
Black | 8,313 (33) | 7,638 (32) | 649 (34) | 26 (36) | |
White | 10,339 (40) | 9,332 (39) | 970 (50) | 37 (51) | |
Asian | 1,149 (4.5) | 1,045 (4.4) | 100 (5.2) | 4 (5.5) | |
Indian/Hawaiian/PI | 484 (1.9) | 449 (1.9) | 34 (1.8) | 1 (1.4) | |
Unknown/Refused | 5,380 (21) | 5,192 (22) | 183 (9.5) | 5 (6.7) | , |
Alcohol abuse | 13,917 (54) | 13,145 (56) | 734 (38) | 38 (52) | <0.001 |
Substance abuse | 5,397 (21) | 4,927 (21) | 434 (22) | 36 (49) | <0.001 |
HCV ab positive | 4,331 (17) | 3,964 (17) | 324 (17) | 43 (59) | <0.001 |
HCV RNA positive | 2,728 (11) | 2501 (11) | 206 (11) | 21 (29) | <0.001 |
HIV co-infection | 1,195 (4.7) | 1,053 (4.5) | 135 (7.0) | 7 (9.6) | <0.001 |
Cirrhosis | 1,937 (7.5) | 1,625 (6.9) | 290 (15) | 22 (30) | <0.001 |
HBV DNA | <0.001 | ||||
<2,000 IU/mL | 3,985 (16) | 3,400 (14) | 562 (29) | 23 (32) | |
2,000–20,000 IU/mL | 512 (2.0) | 425 (1.8) | 87 (4.5) | 0 (0) | |
>20,000 IU/mL | 1,437 (5.6) | 1,104 (4.7) | 330 (17) | 3 (4.1) | |
Not tested | 19,669 (77) | 18,666 (79) | 956 (49) | 47 (64) | |
Peak ALT (median, IQR) (n=16,569) | 49 (29, 105) | 47 (28, 96) | 78 (38, 260) | 84 (44,201) | <0.001 |
High Risk Profile* | 1,468 (25) | 1,181 (24) | 271 (28) | 16 (62) | <0.001 |
Peak Total Bilirubin (median, IQR) (n=16,460) | 0.8 (0.6, 1.2) | 0.8 (0.6, 1.2) | 1.0 (0.7, 1.8) | 1 (0.6, 2.7) | <0.001 |
Peak INR (median, IQR) (n=8,719) | 1.1 (1.0, 1.3) | 1.1 (1.0, 1.3) | 1.1 (1.0, 1.3) | 1.1 (1.0, 1.3) | 0.09 |
Seen by Specialist | 5743 (22) | 4719 (20) | 988(51) | 36(49) | <0.001 |
GI/Hepatology | 3904 (15) | 3134 (13) | 744(38) | 26 (36) | <0.001 |
Infectious Disease | 2172(8.5) | 1832(7.8) | 326(17) | 14(19) | <0.001 |
Abbreviations: M=mean, SD=standard deviation, ALT=alanine aminotransferase, INR=international normalized ratio, IQR=interquartile range
Alcohol abuse/dependence= AUDIT-C score ≥5
Substance abuse/dependence, HIV and cirrhosis identified by ICD-9-CM codes
High risk profile refers to patients with ALT ≥2 ULN and HBV DNA <2,000 IU/mL, (data available for n=5,935)