Table 3.

Factors Associated with HDV-Positive Status

Variable	Unadjusted (OR, 95% CI)	P value	Adjusted (OR, 95% CI)	P value
HCV Ab+	7.1 (4.4–11.5)	<0.001	3.2 (1.4–7.6)	0.007
Alcohol abuse	1.8 (1.1–2.8)	0.016	3.2 (1.4–7.8)	0.009
Cirrhosis	2.4 (1.5–4.1)	0.001	3.5 (1.4–8.5)	0.006
High risk profile*	4.2 (1.9–9.3)	<0.001	3.2 (1.4–7.5)	0.007
HBcIgM+	0.21 (0.07–0.68)	0.009	0.18 (0.02–1.5)	0.107
HBeAg+	0.39 (0.21–070)	0.002	0.50 (0.17–1.4)	0.182
Substance abuse	3.4 (2.1–5.4)	<0.001	2.0 (0.83–5.0)	0.119
Interferon therapy	2.7 (1.2–6.1)	0.016	1.4 (0.27–7.1)	0.693

Abbreviations HBcIgM = hepatitis b core IgM, HCV hepatitis c virus

Substance abuse, cirrhosis obtained using ICD-9-CM codes

Alcohol abuse = score of ≥5 on AUDIT-C questionnaire

^*High risk profile refers to patients with ALT ≥2 ULN and HBV DNA <2,000 IU/mL