Fig 3. Comparative binding analysis of A: natural ligand testosterone (TST) with B: bisphenol A (BPA), C: methylbishydroxyphenylpentene (MBP), and D: 4-tert-octylphenol (OP) in the binding site of human androgen receptor (AR).

The hydrogen bonds are shown as green-dashed lines with indicated bond lengths and the residues involved in hydrophobic interactions are shown as red arcs. The interacting residues which are common for all the ligands are encircled.