Fig 5. Sensitivity analyses for model predictions.

(a) Heatmap for the probability of initiation for a single crypt for ranges of parameters of α ₁ and β ₁. (b) Number of patients out of 100000 samples in which mutant A cells make up a threshold (x-axis) frequency in the ending tumor cell population, for variable shape parameters of the mutational fitness distribution (α ₁,β ₁). (Solid) All patients (Dashed) Patients in which mutation A arose and fixed during the pre-initiation phase. (c) Probability of detecting the passenger mutation in x out of 220 patients for a varying α ₂, β ₂.