Table 1. Parameters of the evolutionary model.

Parameter	Definition	Phase
N	number of cells at risk for accumulating oncogenic mutations	pre-initiation
D	division rate of cells at risk for accumulating oncogenic mutations	pre-initiation
u	overall mutation probability per cell division	both
α 1, β 1	shape parameters of mutational fitness kernel	pre-initiation
b, d	birth/death rate of cell initiating clonal expansion	clonal expansion
α 2, β 2	shape parameters of mutational fitness kernel	clonal expansion
N d	number of cells at time of detection	clonal expansion