Table 3. The estimated associations between resistance of E. coli isolates to an antimicrobial agent and gene expression potential with other confounding variables in STP wastewater. ¹ .

Antimicrobial	Parameter	Coefficient	Standard Error	P-value
Cefotaxime	Constant	-0.689	0.628	0.272
	CYP1B1	0.546	0.274	0.046*
	STP-1	-0.530	0.386	0.170
	STP-3	-0.460	0.571	0.420
	STP-4	-1.233	0.405	0.002*
	Monsoon	-0.624	0.513	0.224
	Step 2	-0.413	0.375	0.271
	Step 3	-0.066	0.379	0.863
	Step 4	0.038	0.355	0.915
Imipenem	Constant	-3.598	0.971	<0.001
	CYP3A2	1.321	0.575	0.022*
	STP-1	0.913	0.764	0.232
	STP-3	-1.694	1.076	0.115
	STP-4	-0.913	0.765	0.233
	Monsoon	-0.656	0.848	0.439
	Step 2	-1.013	0.777	0.192
	Step 3	-0.206	0.776	0.791
	Step 4	0.409	0.677	0.546
Streptomycin	Constant	0.198	0.312	0.525
	CYP2B15	0.613	0.271	0.023*
	STP-1	-0.562	0.358	0.116
	STP-3	-0.919	0.516	0.075
	STP-4	-1.169	0.512	0.022*
	Monsoon	-1.372	0.437	0.002**
	Step 2	-0.876	0.460	0.057
	Step 3	-0.751	0.421	0.074
	Step 4	-0.385	0.360	0.284

¹Data shows if only significant association between an antimicrobial agent and gene expression was found. All other data are given in S2 Table. STP-2, pre-monsoon and Step 1, were assigned as the reference level for the variables of the sewage treatment facility, season and processing step, respectively. The asterisks shown to the P values shows the levels of statistical significance (* <0.05, **<0.01).