Fig 2. The proportion (in %) of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates, for blood isolates (A), male urine isolates (B) and female urine isolates (C) from 2008–2012, ISIS-AR, the Netherlands.

The point-estimates and log-linear trends per year were estimated with a generalized estimation equation (GEE) for log-binominal regression including time in years, and patient characteristics, including age, gender, patient setting and geographic region. The error bars represent the 95% confident intervals of each of the point-estimates.