Table 2. Adjusted risk ratio’s (yRiR) per year for the time trends in proportion of Escherichia coli and Klebsiella pneumoniae isolates resistant to third generation cephalosporins, ISIS-AR, The Netherlands, 2008–2012.

	yRiR a	[95% CI]
Blood
E. coli	1.15	[1.09–1.20]
K. pneumoniae	1.11	[1.00–1.23]
Urine from males
E. coli	1.13	[1.10–1.16]
K. pneumoniae	1.12	[1.07–1.18]
Urine from females
E. coli	1.07	[1.05–1.09]
K. pneumoniae	1.16	[1.11–1.21]

^aAdjusted yearly risk ratio’s (yRiR) and 95% confidence intervals (95% CI) are generated with a log-binomial regression, adjusted for patient characteristics, including age, gender, patient setting and geographic region, and corrected for repeated measures using generalized estimating equation (GEE).