Table 3. Association between individual SNP and colorectal cancer risk.
| Genotype | Controls (%) | Cases (%) | P a | OR (95%CI) b | P b |
|---|---|---|---|---|---|
| rs2193941 | |||||
| AA | 310(44.4) | 277(41.3) | 0.516 | 1.000 | |
| AG | 305(43.7) | 310(46.3) | 1.142 (0.909–1.434) | 0.253 | |
| GG | 83(11.9) | 83(12.4) | 1.102 (0.779–1.560) | 0.583 | |
| Dominant model | 1.131(0.912–1.403) | 0.263 | |||
| Recessive model | 1.040(0.750–1.442) | 0.813 | |||
| Additive model | 1.078(0.921–1.263) | 0.350 | |||
| rs17716310 | |||||
| AA | 337(48.4) | 294(43.1) | 0.117 | 1.000 | |
| AC | 284(40.7) | 314(46.0) | 1.273 (1.016–1.595) | 0.036 | |
| CC | 76(10.9) | 74(10.9) | 1.104 (0.771–1.581) | 0.589 | |
| Dominant model | 1.238(1.000–1.532) | 0.050 | |||
| Recessive model | 0.987(0.702–1.388) | 0.939 | |||
| Additive model | 1.123(0.958–1.318) | 0.153 | |||
| rs7703385 | |||||
| CC | 324(47.2) | 294(43.2) | 0.310 | 1.000 | |
| CG | 290(42.3) | 313(45.9) | 1.194 (0.952–1.497) | 0.125 | |
| GG | 72(10.5) | 74(10.9) | 1.117 (0.776–1.606) | 0.553 | |
| Dominant model | 1.176(0.949–1.458) | 0.138 | |||
| Recessive model | 1.031(0.730–1.457) | 0.862 | |||
| Additive model | 1.103(0.939–1.296) | 0.232 |
Abbreviations: OR, Odds ratio; 95%CI, 95% confidence interval.
a P values were calculated by the Pearson Chi-Square test
b Data were calculated by logistic regression model after adjusting for sex, age group and smoking status.
The nominal significant and marginal results were in bold.