Fig 7. Propofol increases host susceptibility to S. aureus infection.
(a). Mice were intravenously infected with 1 x 106 CFU S. aureus USA300 ± propofol and kidneys were isolated at 14 days post-infection. Arrows: abscess formation. (b). Levels of inflammation and necrosis in the kidney expressed as percentage of histological sections ± SEM, with 5–6 animals per group. (c). Mice were infected with 1 x 106 CFU S. aureus USA300 ± propofol and sacrificed at 7 days post-infection. Kidneys were fixed and processed for H&E staining. Propofol increased inflammation, caused the loss of kidney compartmentalization, and increased the number and size of abscesses. Left: images from 2 mice infected with S. aureus USA300 without propofol. Right: images from 2 mice infected with S. aureus USA300 with propofol. Top: 2x magnification; bottom: 20x magnification.