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. 2015 Sep 18;10(9):e0136265. doi: 10.1371/journal.pone.0136265

Table 2. Comparisons in studies regarding local oestrogen treatment for urinary incontinence and/or overactive bladder symptoms.

Intervention Comparison Studies
Vaginal oestrogen versus placebo or no treatment
Oestrogen 0,025–3 mg Placebo Simunic et al. 2003; Cardozo et al. 2001; Dessole et al. 2004; Sacco et al. 1990; Enzelsberger 1991–1; Enzelsberger 1991–2
Triple therapy (local oestrogen (dose unclear), physiotherapy and electrostimulation) No treatment Holtedahl et al. 1998
Premarin cream 2 gr/night (1.25 mg oestrogen) No treatment Henalla et al. 1989; Henalla et al. 1990
Different application methods of vaginal oestrogen
Oestrogen Ring 0,5mg Oestrogen Pessary 0,5mg Lose et al. 2000
Vaginal oestrogen versus non-hormonal treatment
Oestrogen cream 0,625mg + tolterodine Tolterodine Tseng et al. 2009; Serati et al. 2009
Oestrogen ring 1mg (7,5microgram/24hr) Oral oxybutynin Nelken et al. 2011
Oestrogen suppository 1mg Phenylpropanolamine Beisland et al. 1984
Premarin cream 2 gr/night (1.25 mg oestrogen) Pelvic floor exercises Henalla et al. 1989; Henalla et al. 1990
Premarin cream 2 gr/night (1.25 mg oestrogen) Electrostimulation Henalla et al. 1989
Different doses of vaginal oestrogen
1mg (application form unclear) 3mg (application form unclear) Enzelsberger 1991
0,5-1mg (application form unclear) 2mg (application form unclear) Enzelsberger 1990
Vaginal oestrogen versus oral oestrogen
Oestrogen cream 0,625mg Oral oestrogen 0,625mg Long et al. 2006
Vaginal oestrogen vs combination therapy
Oestrogen ovule 1mg + PFR Oestrogen Ovule 1mg Capobianco et al. 2012
Triple therapy: Oestrogen and Lactobacilli Acidophili ovule plus pelvic floor rehabilitation (1mg oestrogen + 50 mg lyophilisate) Oestrogen ovule plus pelvic floor rehabilitation (1mg oestrogen) Capobianco et al. 2014